Research

Other Conditions

The following section lists a collection of published research studies for various other conditions including autoimmune diseases (such as rheumatoid arthritis and systemic lupus erythematous), neurodegenerative/cognitive conditions (such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease), spinal cord injury, inflammatory bowel disease, lung disease (such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease), erectile dysfunction, diabetes (type I and type II) and more.

We included studies that used various routes of administration and cell types and studies published beyond the past 5 years. We also included systematic reviews and meta-analyses for additional evidence. To view the abstracts or full texts use the provided links listed below the study title.

Rheumatoid Arthritis

• Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran. Ghoryani, M., Shariati-Sarabi, Z., Tavakkol-Afshari, J., Ghasemi, A., Poursamimi, J., & Mohammadi, M. (2019). Biomedicine and Pharmacotherapy, 109, 1834–1840. https://doi.org/10.1016/j.biopha.2018.11.056
• Intra-articular knee implantation of autologous bone marrow–derived mesenchymal stromal cells in rheumatoid arthritis patients with knee involvement: Results of a randomized, triple-blind, placebo-controlled phase 1/2 clinical trial. Shadmanfar, S., Labibzadeh, N., Emadedin, M., Jaroughi, N., Azimian, V., Mardpour, S., … Aghdami, N. (2018). Cytotherapy. https://doi.org/10.1016/j.jcyt.2017.12.009
• Intravenous Infusion of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Rheumatoid Arthritis: A Phase Ia Clinical Trial. Park, E. H., Lim, H. suk, Lee, S., Roh, K., Seo, K. W., Kang, K. S., & Shin, K. (2018). Stem Cells Translational Medicine, 7(9), 636–642. https://doi.org/10.1002/sctm.18-0031

Lupus

• A randomised double-blind, placebo-controlled trial of allogeneic umbilical cord-derived mesenchymal stem cell for lupus nephritis.Deng, D., Zhang, P., Guo, Y., & Lim, T. O. (2017). Annals of the Rheumatic Diseases, 76(8), 1436–1439. https://doi.org/10.1136/annrheumdis-2017-211073
• Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: A multicenter clinical study. Wang, D., Li, J., Zhang, Y., Zhang, M., Chen, J., Li, X., … Sun, L. (2014). Arthritis Research and Therapy, 16(2), R79. https://doi.org/10.1186/ar4520
• Allogeneic mesenchymal stem cell transplantation for lupus nephritis patients refractory to conventional therapy. Gu, F., Wang, D., Zhang, H., Feng, X., Gilkeson, G. S., Shi, S., & Sun, L. (2014). Clinical Rheumatology, 33(11), 1611–1619. https://doi.org/10.1007/s10067-014-2754-4
• Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Wang, D., Zhang, H., Liang, J., Li, X., Feng, X., Wang, H., … Sun, L. (2013). Cell Transplantation, 22(12), 2267–2277. https://doi.org/10.3727/096368911X582769

Amyolateral Sclerosis

• Oh, K.-W., Noh, M.-Y., Kwon, M.-S., Kim, H. Y., Oh, S.-I., Park, J., … Kim, S. H. (2018). Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis. Annals of Neurology, 84(3), 361–373. https://doi.org/10.1002/ana.25302
• Syková, E., Rychmach, P., Drahorádová, I., Konrádová, Ši., Růžičková, K., Voříšek, I., … Bojar, M. (2017). Transplantation of Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial. Cell Transplantation. https://doi.org/10.3727/096368916×693716
• Petrou, P., Gothelf, Y., Argov, Z., Gotkine, M., Levy, Y. S., Kassis, I., … Karussis, D. (2016). Safety and clinical effects of mesenchymal stem cells secreting neurotrophic factor transplantation in patients with amyotrophic lateral sclerosis. JAMA Neurology. https://doi.org/10.1001/jamaneurol.2015.4321
• Staff, N. P., Madigan, N. N., Morris, J., Jentoft, M., Sorenson, E. J., Butler, G., … Windebank, A. J. (2016). Safety of intrathecal autologous adipose-derived mesenchymal stromal cells in patients with ALS. Neurology. https://doi.org/10.1212/WNL.0000000000003359
• Glass, J. D., Hertzberg, V. S., Boulis, N. M., Riley, J., Federici, T., Polak, M., … Feldman, E. L. (2016). Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials. Neurology. https://doi.org/10.1212/WNL.0000000000002889

Parkinson’s Disease

• Schiess, M., Suescun, J., Ellmore, T., Doursout, M.-F., Furr-Stimming, E., Miao, H., … Gee, A. (2019). Preliminary Report on the Safety and Tolerability of Bone marrow-derived Allogeneic Mesenchymal Stem Cells infused intravenously in Parkinson’s disease Patients (S16.008). Neurology, 92(15 Supplement). https://n.neurology.org/content/92/15_Supplement/S16.008
• Kern, R., Garitaonandia, I., Gonzalez, R., Sherman, G., Semechkin, A., Braine, E., … Evans, A. (2019). Results of an Open Label, Dose Escalating, Phase 1 Clinical Trial Evaluating the Safety of a Human Neural Stem Cell Based Therapy in Parkinson’s Disease (P1.8-016). Neurology, 92(15 Supplement). https://n.neurology.org/content/92/15_Supplement/P1.8-016

Alzheimer’s Disease / Vascular Dementia

• He, Y., Jin, X., Wang, J., Meng, M., Hou, Z., Tian, W., … Fu, L. (2017). Umbilical cord-derived mesenchymal stem cell transplantation for treating elderly vascular dementia. Cell and Tissue Banking, 18(1), 53–59. https://doi.org/10.1007/s10561-017-9609-6
• Kang, J. M., Yeon, B. K., Cho, S. J., & Suh, Y. H. (2016). Stem Cell Therapy for Alzheimer’s Disease: A Review of Recent Clinical Trials. Journal of Alzheimer’s Disease. https://doi.org/10.3233/JAD-160406
• Kim, H. J., Seo, S. W., Chang, J. W., Lee, J. Il, Kim, C. H., Chin, J., … Na, D. L. (2015). Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: A phase 1 clinical trial. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, 1(2), 95–102. https://doi.org/10.1016/j.trci.2015.06.007

Spinal Cord Injury

• Vaquero, J., Zurita, M., Rico, M. A., Aguayo, C., Bonilla, C., Marin, E., … Ovejero, M. (2018). Intrathecal administration of autologous mesenchymal stromal cells for spinal cord injury: Safety and efficacy of the 100/3 guideline. https://doi.org/10.1016/j.jcyt.2018.03.032
• Larocca, T. F., Macêdo, C. T., Souza, B. S. de F., Andrade-Souza, Y. M., Villarreal, C. F., Matos, A. C., … Dos Santos, R. R. (2017). Image-guided percutaneous intralesional administration of mesenchymal stromal cells in subjects with chronic complete spinal cord injury: a pilot study. Cytotherapy, 19(10), 1189–1196. https://doi.org/10.1016/j.jcyt.2017.06.006
• J.W., H., T.-H., C., D.-H., P., J.-B., L., J.-Y., P., Y.-G., C., … Chung, Y.-G. (2016). Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. The Journal of Spinal Cord Medicine. https://doi.org/10.1179/2045772315Y.0000000048

Inflammatory Bowel Disease

• Shi, X., Chen, Q., & Wang, F. (2019). Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies. Stem Cell Research & Therapy, 10(1), 266. https://doi.org/10.1186/s13287-019-1336-4
• Barnhoorn, M. C., Wasser, M. N. J. M., Roelofs, H., Maljaars, P. W. J., Molendijk, I., Bonsing, B. A., … van der Meulen-de Jong, A. E. (2019). Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn’s Disease Perianal Fistulas. Journal of Crohn’s and Colitis. https://doi.org/10.1093/ecco-jcc/jjz116
• Cheng, F., Huang, Z., & Li, Z. (2019). Mesenchymal stem-cell therapy for perianal fistulas in Crohn’s disease: a systematic review and meta-analysis. Techniques in Coloproctology. https://doi.org/10.1007/s10151-019-02024-8
• Serrero, M., Grimaud, F., Philandrianos, C., Visée, C., Sabatier, F., & Grimaud, J. C. (2019). Long-term Safety and Efficacy of Local Microinjection Combining Autologous Microfat and Adipose-Derived Stromal Vascular Fraction for the Treatment of Refractory Perianal Fistula in Crohn’s Disease. Gastroenterology, 156(8), 2335-2337.e2. https://doi.org/10.1053/j.gastro.2019.01.032
• Dige, A., Hougaard, H. T., Agnholt, J., Pedersen, B. G., Tencerova, M., Kassem, M., … Lundby, L. (2019). Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn’s Disease. Gastroenterology, 156(8), 2208-2216.e1. https://doi.org/10.1053/j.gastro.2019.02.005

Lung Disease

• Averyanov, A., Koroleva, I., Konoplyannikov, M., Revkova, V., Lesnyak, V., Kalsin, V., … Baklaushev, V. (2019). First‐in‐human high‐cumulative‐dose stem cell therapy in idiopathic pulmonary fibrosis with rapid lung function decline. STEM CELLS Translational Medicine, sctm.19-0037. https://doi.org/10.1002/sctm.19-0037
• Fishman, J. E., Kim, G. J., Kyeong, N., Goldin, J. G., & Glassberg, M. K. (2019). Intravenous stem cell dose and changes in quantitative lung fibrosis and DLCO in the AETHER trial : a pilot study. 1, 7568–7572. https://www.ncbi.nlm.nih.gov/pubmed/31539148
• Ntolios, P., Manoloudi, E., Tzouvelekis, A., Bouros, E., Steiropoulos, P., Anevlavis, S., … Froudarakis, M. E. (2018). Longitudinal outcomes of patients enrolled in a phase Ib clinical trial of the adipose-derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis. Clinical Respiratory Journal, 12(6), 2084–2089. https://doi.org/10.1111/crj.12777
• Zhang, C., Yin, X., Zhang, J., Ao, Q., Gu, Y., & Liu, Y. (2017). Clinical observation of umbilical cord mesenchymal stem cell treatment of severe idiopathic pulmonary fibrosis: A case report. Experimental and Therapeutic Medicine, 13(5), 1922–1926. https://doi.org/10.3892/etm.2017.4222

Male Sexual Dysfunction

• Haney, N. M., Gabrielson, A., Kohn, T. P., & Hellstrom, W. J. G. (2019). The Use of Stromal Vascular Fraction in the Treatment of Male Sexual Dysfunction: A Review of Preclinical and Clinical Studies. Sexual Medicine Reviews, 7(2), 313–320. https://doi.org/10.1016/j.sxmr.2018.04.001
• Zhang, C., Luo, D., Li, T., Yang, Q., Xie, Y., Chen, H., … Liu, G. (2019). Transplantation of Human Urine-Derived Stem Cells Ameliorates Erectile Function and Cavernosal Endothelial Function by Promoting Autophagy of Corpus Cavernosal Endothelial Cells in Diabetic Erectile Dysfunction Rats. Stem Cells International, 2019, 1–13. https://doi.org/10.1155/2019/2168709
• Chung, E. (2019). Stem cell therapy in diabetic men with erectile dysfunction: a step closer to safe and effective regenerative technology. Annals of Translational Medicine, 7(Suppl 1), S40. https://doi.org/10.21037/atm.2019.02.28
• Lokeshwar, S. D., Patel, P., Shah, S. M., & Ramasamy, R. (2019). A Systematic Review of Human Trials Using Stem Cell Therapy for Erectile Dysfunction. Sexual Medicine Reviews. https://doi.org/10.1016/j.sxmr.2019.08.003

Diabetes

• Sheykhhasan, M. (2019). Towards Standardized Stem Cell Therapy in Type 2 Diabetes Mellitus: A Systematic Review. Current Stem Cell Research & Therapy, 14(1), 75–76. https://doi.org/10.2174/1574888×1401181217125608
• Stiner, R., Alexander, M., Liu, G., Liao, W., Liu, Y., Yu, J., … Lakey, J. R. T. (2019). Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes. Cell and Tissue Research. https://doi.org/10.1007/s00441-019-03046-2
• Aziz, J., Liao, G., Adams, Z., Rizk, M., Shorr, R., & Allan, D. S. (2019). Systematic review of controlled clinical studies using umbilical cord blood for regenerative therapy: Identifying barriers to assessing efficacy. Cytotherapy. https://doi.org/10.1016/j.jcyt.2019.08.004
• Estrada, E. J., Decima, J. L., Bortman, G., Roberti, J., Romero, E. B., Samaja, G., … Gutiérrez, S. (2019). Combination treatment of autologous bone marrow stem cell transplantation and hyperbaric oxygen therapy for type 2 diabetes mellitus: A randomized controlled trial. Cell Transplantation, 096368971988381. https://doi.org/10.1177/0963689719883813
• Cho, J., D’Antuono, M., Glicksman, M., Wang, J., & Jonklaas, J. (2018). A review of clinical trials: mesenchymal stem cell transplant therapy in type 1 and type 2 diabetes mellitus. American Journal of Stem Cells, 7(4), 82–93. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/30510843
• Bhansali, S., Dutta, P., Kumar, V., Yadav, M. K., Jain, A., Mudaliar, S., … Bhansali, A. (2017). Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell and Mononuclear Cell Transplantation in Type 2 Diabetes Mellitus: A Randomized, Placebo-Controlled Comparative Study. Stem Cells and Development, 26(7), 471–481. https://doi.org/10.1089/scd.2016.0275